S2 Translational research 1 : Muscle metabolism and exercise |
09:00~11:00 / Friday 7 October Convention Hall B, 4F Chairman:Kwanwoo Lee, Cheol Soo Choi |
Overview |
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In this era of obesity epidemic, the need for metabolic recovery through exercise is becoming increasingly important, whose effects can be mediated by mitochondria in skeletal muscle. Four speakers will present in this session on the most recent research into novel mechanisms regulating mitochondrial function, the reciprocal relationships between exercise and mitochondria, and the resulting metabolic changes. This session will be a cornerstone to understand more precise mechanism and action of muscle metabolism related to exercise. | ||
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S2-1Two-dimensional study of drug timing to reconvert glucocorticoids into striated muscle boosters and counteract metabolic dysfunction | |
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S2-2Mitochondrial plasticity and skeletal muscle fitness | |
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S2-3TAZ links exercise to mitochondrial biogenesis and insulin sensitivity | |
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S2-4Tracing metabolic flux in vivo using stable isotope tracers: effects of exercise training and obesity |
S5 Basic Research 1 : Adaptation of beta cell to stress |
09:00~11:00 / Friday 7 October Emerald Hall B, 3F Chairman:Rohit N. Kulkarni , Hail Kim |
Overview |
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Pancreatic β-cells are essential to maintain blood glucose level in response to the metabolic demand. Significant loss of functional β cell mass contributes to the development of diabetes. Therefore, maintaining functional β cell mass is crucial to treat diabetes in pathophysiological perspective. For this reason, researchers have asked questions on how β cells can respond to and compensate for metabolic stress for many years. In this session, four outstanding speakers will discuss how β-cells adapt to metabolic stress and regulate their original function when they experience cellular stress in response to metabolic stress. Prof. Jun Sung Moon and Jaemin Lee will present their recent data how oxidative stress and ER stress affect β-cell function. Prof. Rohit Kulkarni will show the significance of mRNA modification in the regulation of β-cell function. Prof. Shugo Sasaki will present his recent data about β-cell heterogeneity during neogenesis. | ||
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S5-1Endoplasmic reticulum stress in pancreatic β-cells induces incretin desensitization and β-cell dysfunction via ATF4 | |
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S5-2Therapeutic modulation of antioxidant system for damaged β-cell | |
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S5-3Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system | |
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S5-4The significance of mRNA modifications in the regulation of islet biology |
S13 Translational research 2 : Novel markers of the cardio-metabolic disorders |
09:00~11:00 / Saturday 8 October Emerald Hall B, 3F Chairman:Dongsun Kim, Choon Hee Chung |
Overview |
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Early prediction of disease onset, response rate and prognosis are becoming a major issue in managing metabolic diseases. This session is a translational session aimed to provide a novel insight for clinicians and basic researchers to tailor cardiovascular diseases and metabolic diseases in terms of biomarkers. In the session, four distinguished speakers will present their latest studies regarding novel metaboliomics/lipidmoics and other biomarkers on cardiovascular disease, non-alcoholic fatty liver diseases and etc. This session will hopefully help audiences to understand the role of novel markers in cardio-metabolic diseases. | ||
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S13-1Metabolomics profiling provides potential novel biomarkers for the impact of diet quality on cardiometabolic disease risk | |
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S13-2Lipidome in non-alcoholic fatty liver disease: pathways, metabolic models, and biomarkers | |
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S13-3Organokines & other potential biomarkers for cardiometabolic disorders | |
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S13-4Potential molecular transducer of exercise-induced cardiac adaptation |
S18 Basic Research 2 : Adipose tissue as a moderator of systemic metabolism |
13:30~15:30 / Saturday 8 October Emerald Hall B, 3F Chairman:Bong-Soo Cha, Byung-Hyun Park |
Overview |
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To maintain energy balance, adipocytes switch between anabolic and catabolic metabolism, and dysregulation of this capacity has long been thought to be the origin and/or primary foe of metabolic diseases.Understanding how unhealthy adipose tissue promotes type 2 diabetes, cardiovascular disease, and certain types of cancer is critical to fighting against such diseases. Over the last two decades, scientific breakthroughs such as the discovery of brown adipose tissue in adult humans, characterization of beige/brite adipocytes in subcutaneous adipose tissue, and deconvoluting adipose heterogeneity using single-cell technologies have expanded our understanding with respect to their roles in systemic energy homeostasis. In this session, four speakers will review the current advances in adipose biology, such as the fundamental role of adipose tissue in metabolic health, the dynamic remodeling of adipose tissue, and the qualitative understanding of metabolic rate and flux in brown adipose tissues. | ||
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S18-1Dynamic remodeling of adipose tissue for survival | |
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S18-2Brown adipose tissue and systemic lipoprotein metabolism | |
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S18-3Adipose tissue and metabolic health | |
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S18-4Metabolic flux in brown adipose tissue and its regulation by nutrient sensing pathways |